C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 281/08 (2006.01) A61K 31/55 (2006.01) C07D 281/10 (2006.01) C07D 417/00 (2006.01) C07D 417/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2156183
The invention provides a compound of formula (1), wherein I is an integer of from 0 to 4; n is an integer of from 0 to 2; X is an aromatic or non-aromatic monocyclic or bicyclic ring system having from 5 to 10 carbon atoms (including the two carbon atoms forming part of the thiazepine ring) wherein optionally one or more of the carbon atoms is/are replaced by heteroatom(s) independently selected from nitrogen, oxygen and sulphur, with the proviso that at least one of R, R2, R4 and R5 is hydroxy or a group containing hydroxy; and salts, solvates and physiologically functional derivatives thereof, pharmaceutical formulations comprising such compounds, processes for their preparation and their use in reducing bile acid uptake and hence as hypolipidaemic agents.
Brieaddy Lawrence Edward
Hodgson Gordon Lewis Jr.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Wellcome Foundation Limited
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