C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/385, 260/328
C07D 333/32 (2006.01) C07D 333/38 (2006.01)
Patent
CA 1078852
Abstract of the Disclosure Substituted thiophen?carboxylic acids and esters and pharmaceutically acceptable salts thereof of the following general structure are useful as hypolipidemic agents: Image wherein R is selected from a straight or branched saturated hydrocarbon chain containing from 10 to 20 carbon atoms and a straight or branched unsaturated hydrocarbon chain containing from 10 to 20 carbon atoms and from 1 to 4 double bonds; R1 is selected from hydrogen, a straight or branched lower alkyl chain of from 1 to 6 carbon atoms, benzyl, phenethyl, pyridyl- methyl, alkane-poly-yl containing from 3 to 6 carbon atom;, 1,2,3,4,5,6-cyclohexanehexayl, and Z; Z is selected from (A) the group Image wherein n is the integer 2 or 3; R2 is selected from a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, and alkylcarbonyl wherein the alkyl moiety contains from 1 to 4 carbon atoms and may be straight or branched; R3 is selected from hydrogen and a straight or branched lower alkyl chain of from 1 to 4 carbon atoms with the proviso that when R3 is hydrogen, R2 is alkyl- carbonyl; or when R2 is other than alkylcarbonyl, R2 and R3 taken together with the nitrogen atom to which each is attached form a monocyclic heterocycilc group selected from pyrrolidino, piperidino, morpholino, and piperazino; or (B) the group Image wherein the sum of the inte- gers m and p is equal to from 3 to 5; and R4 is a straight or branched lower alkyl chain of from 1 to 4 carbon atoms; X is an integer of from 1 to 6 with the proviso that when R1 is alkane-poly-yl or 1,2,3,4,5,6-cyclohexanehexayl, X is equal to from 2 to 6, and when R1 is other than alkane-poly-yl or 1,2,3,4,5,6-cyclohexanehexayl, X is equal to 1.
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