Hyposensitization agent

Details Hyposensitization agent Hyposensitization agent

C - Chemistry, Metallurgy

07

K

530/17.1, 167/10

C07K 17/10 (2006.01) A61K 38/14 (2006.01) A61K 39/36 (2006.01)

Patent

CA 2024167

10228085 Abstract of the Disclosure A novel hyposensitization agent was prepared by covalently attaching a saccharide to a cedar pollen allergen having a partial amino acid sequence of Ala-Ile-Asn-Ile-Phe- Asn- beginning at its N-terminal. The hyposensitization agent, when compared with an intact cedar pollen allergen, extremely accelerates the production of immunoglobulin G and M antibodies which are specific to intact cedar pollen allergen, but extremely reduces the production of immunoglobulin E antibody which is specific to the allergen. Thus, the hyposensitization agent is administrable to cedar pollinosis patients with no anaphylaxis and allergy, and cuts hyposensitization period to about 1/3 to 1/200.

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