Hypotensive agents

Details Hypotensive agents Hypotensive agents

C - Chemistry, Metallurgy

07

D

260/264.3

C07D 487/04 (2006.01) C07C 51/08 (2006.01) C07D 237/04 (2006.01) C07D 237/08 (2006.01) C07D 237/12 (2006.01) C07D 237/14 (2006.01) C07D 237/20 (2006.01) C07D 295/145 (2006.01)

Patent

CA 1080712

ABSTRACT OF THE DISCLOSURE This disclosure describes novel phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines and processes for thier prep- aration of formula I Image wherein R1, R2, and R3 are each individually selected from the group consist- ing of hydrogen and alkyl of up to 3 carbon atoms, and R4 is hydrogen or one or more groups which may be the same or different chosen from fluoro, chloro, bromo, cyano, trifluoromethyl, nitro, amino, acetamido, carbamoyl, thiocarbamoyl, or alkyl of up to 4 carbon atoms, provided that (a) at least one of R1 and R2 is hydrogen; (b) when R1, R2 and R4 are all hydrogen, then R3 is other than methyl; and (c) when R2 and R3 are both methyl, then both R1 and R4 are other than hydrogen. These compounds find use as hypotensive agents and anxiolytic agents.

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