C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2222279
The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1.alpha. and HIF-1.beta.. Purified HIF-1.alpha. polypeptide, its amino acid sequence and polynucleotide sequence are provided. A HIF-1.alpha. variant that dimerizes to HIF-1.beta. producing a nonfunctional HIF-1 complex is described. Methods for the prevention and treatment of hypoxia-related disorders are provided.
Facteur 1 pouvant être induit par l'hypoxie (HIF-1), qui est composé de sous-unités HIF-1.alpha. et HIF-1.beta.. La présente invention concerne le polypeptide HIF-1.alpha. purifié, sa séquence d'acides aminés et sa séquence polynucléotidique, un variant HIF-1.alpha. qui dimérise avec HIF-1.beta., produisant un complexe HIF-1 non fonctionnel, ainsi que des procédés de prévention et de traitement de troubles liés à l'hypoxie.
Mbm Intellectual Property Law Llp
The Johns Hopkins University School Of Medicine
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