Hypoxia inducible promoter

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/00 (2006.01) A61K 48/00 (2006.01) C12N 9/88 (2006.01) C12N 15/82 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2303402

The present invention is directed to nucleic acid sequences encoding a novel regulatory element that induces a high level of expression to operably linked genes, upon exposure to hypoxic conditions. Furthermore, the regulatory element can be used to prepare an expression vector for transforming plant cells, wherein the DNA construct comprises a hypoxia inducible promoter operably linked to a gene sequence.

L'invention concerne des séquences d'acide nucléique codant pour un nouvel élément régulateur qui, lorsqu'il est exposé à des conditions d'hypoxie, induit un haut niveau d'expression de gènes liés fonctionnellement à cet élément. Cet élément régulateur peut en outre être utilisé dans la préparation d'un vecteur d'expression permettant la transformation de cellules végétales, dans lequel la structure d'ADN comprend un promoteur adaptatif activé en hypoxie, lié fonctionnellement à une séquence génétique.

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