C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 2/00 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) C07K 5/083 (2006.01) C07K 5/09 (2006.01) C07K 7/06 (2006.01)
Patent
CA 2310027
The invention relates to novel peptides synthesized according to a method utilizing the hypusine reagent of formula (1) wherein Q1, Q2, and Q3 may be the same or different and are amino protective groups, provided that Q3 is orthogonal to Q1 and Q2; and Z is a hydroxy protective group, as well as improved methods of peptide synthesis wherein the above-described hypusine reagent is employed to prepare novel hypusine-containing peptides.
L'invention concerne de nouveaux peptides synthétiques de la formule (1) obtenus suivant un procédé qui met en oeuvre le réactif d'hypusine. Dans ladite formule, Q¿1?, Q¿2? et Q¿3? peuvent être identiques ou différents et sont des groupes de protection amines, à condition que Q¿3? soit orthogonal relativement à Q¿1? et Q¿2?; et Z est un groupe de protection hydroxy. L'invention concerne également des procédés améliorés de synthèse peptidique mettant en oeuvre ledit réactif d'hypusine pour préparer de nouveaux peptides contenant hypusine.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Of Florida Research Foundation Inc.
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