Iap binding compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/06 (2006.01) A61K 31/40 (2006.01) A61P 35/00 (2006.01) C07D 207/09 (2006.01) C07D 403/06 (2006.01) C07D 491/147 (2006.01) C07D 491/153 (2006.01)

Patent

CA 2574040

IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kd of less that 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposes are also disclosed.

L'invention concerne des molécules de liaison aux protéines IAP et des compositions comprenant lesdites molécules. Ces molécules de liaison aux protéines IAP interagissent avec lesdites protéines IAP (protéines inhibitrices de l'apoptose) dans des cellules et peuvent être utilisées pour modifier l'apoptose dans les cellules traitées par lesdites molécules. Dans certains modes de réalisation, les composés de l'invention présentent une constante Kd inférieure à 0,1 micromole. L'invention concerne également des procédés d'utilisation desdites molécules de liaison aux protéines IAP à des fins thérapeutiques, diagnostiques, et d'analyse.

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