Iap inhibitors

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/06 (2006.01) A61K 38/05 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07K 5/062 (2006.01) C07K 5/083 (2006.01)

Patent

CA 2712604

The present invention describes compounds of the following formula: processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. The compounds of the present invention inhibit IAPs (inhibitors of apoptosis proteins) and thus are useful in the treatment of cancer, autoimmune diseases and other disorders where a defect in apoptosis is implicated.

La présente invention concerne des composés de la formule suivante, des procédés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en thérapie. Les composés de la présente invention inhibent les inhibiteurs de protéines d'apoptose (IAP), et sont ainsi utiles dans le traitement du cancer, des maladies auto-immunes et d'autres troubles pour lesquels un défaut d'apoptose est impliqué.

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