Ibudilast for inhibiting macrophage migration inhibitory...

Details Ibudilast for inhibiting macrophage migration inhibitory... Ibudilast for inhibiting macrophage migration inhibitory...

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61P 25/00 (2006.01) A61P 25/30 (2006.01) A61P 25/32 (2006.01) A61P 25/34 (2006.01) A61P 25/36 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2653345

Methods of antagonizing MIF activity using ibudilast are described. Also described are methods of screening for MIF antagonists. These agents can be used for treating addictions, including drug and behavioral addictions, as well as for treating neuropathic pain.

La présente invention concerne des procédés destinés à inhiber l'activité du facteur inhibiteur de la migration des macrophages (MIF) à l'aide d'ibudilast. L'invention concerne également des procédés de criblage destinés à déterminer les antagonistes du MIF. Ces agents peuvent être utilisés pour le traitement d'accoutumances, incluant la toxicomanie et les penchants malsains, ainsi que pour le traitement d'une douleur névropathique.

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