A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/192 (2006.01) A61K 9/48 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2382292
Liquid softgel fill formulations containing ibuprofen in free acid form, and softgel capsules comprised of a gelatin sheath enclosing such fill formulations, are prepared by dissolving more than 30 % of ibuprofen in free acid form in polyethylene glycol and at least 10 % by weight of a polyvinylpyrrolidone having an average molecular weight of from about 2,000 to about 54,000. The formulations may also include a surfactant to increase the bioavailability of the ibuprofen.
L'invention concerne des formulations de remplissage de gel mou liquide contenant de l'ibuprofène sous forme acide libre, ainsi que des capsules de gel mou constituées d'une enveloppe en gélatine renfermant de telles formulations de remplissage. Leur préparation consiste à dissoudre plus de 30 % d'ibupropène sous forme acide libre dans du polyéthylèneglycol et au moins 10 % en poids d'un polyvinylpyrrolidone de masse moléculaire moyenne allant d'environ 2000 à environ 54000. Ces formulations peuvent également comprendre un tensioactif destiné à accroître la biodisponibilité de l'ibuprofène.
Banner Pharmacaps Inc.
Ridout & Maybee Llp
LandOfFree
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