Ibuprofen for topical administration

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/22 (2006.01) A61K 9/08 (2006.01) A61K 47/18 (2006.01) A61K 31/192 (2006.01)

Patent

CA 2749941

Set forth herein is a preparation of ibuprofen (2-(4--isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a phar- maceutically acceptable solvent so as to produce a topical drug formula-tion compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skm tissue Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e g, a pyrrohdone solvent or dimethylacetamide

La présente invention concerne une préparation d'ibuprofène (acide 2-(4-isobutylphényl)propionique) sous la forme d'acide libre qui est appropriée pour une administration topique. La formulation topique d'ibuprofène est préparée en dissolvant la forme d'acide libre d'ibuprofène, ou en préparant une suspension homogène de la forme d'acide libre d'ibuprofène, en présence d'un solvant pharmaceutiquement acceptable de sorte à produire une formulation topique de médicament compatible avec la pénétration de l'acide 2-(4-isobutylphényl)propionique à travers les tissus de la peau. Les formulations topiques d'ibuprofène peuvent être à base d'un solvant pharmaceutiquement acceptable tel que, par exemple, un solvant pyrrolidone ou diméthylacétamide.

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