Ibuprofen sustained release matrix and process

A - Human Necessities – 61 – K

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167/262

A61K 31/19 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/24 (2006.01)

Patent

CA 1310272

ABSTRACT An ibuprofen-sustained release tablet or tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with ibuprofen, ethylcellulose, a wicking agent e.g. microcrystalline cellulose, an erosion promoter e.g. pregelatinized starch, then drying and milling the granulation and blending with dry powdered erosion promotor, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results is a long-lasting slow and relatively regular incremental release of the ibuprofen.

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