A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2578940
The present invention relates to a method for stimulating expression of peptide hormones in peptide-hormone secreting endocrine cells or neurons comprising the step of promoting in said cells the presence or activity of ICA512, a derivative or a fragment thereof that may be cleaved by mu-calpain giving rise to a C-terminal fragment of ICA512 having the capability to be targeted to the nucleus. It is preferred that said endocrine cells are beta~cells and that said peptide hormone is insulin.
Cette invention concerne un procédé servant à stimuler l'expression d'hormones peptidiques dans des neurones ou des cellules endocrines sécrétant des hormones peptidiques et consistant à cet effet à promouvoir dans ces cellules la présence ou l'activité de la protéine ICA512 ou d'un dérivé ou d'un fragment de celle-ci qui peut être clivé pour produire un fragment terminal C de protéine ICA512 pouvant être ciblé sur le noyau. Il est préférable que ces cellules endocrines soient des cellules bêta et que cette hormone peptidique soit l'insuline.
Mziaut Hassan
Solimena Michele
Trajkovski Mirko
Boehringer Ingelheim International Gmbh
Goudreau Gage Dubuc
Technische Universitat Dresden
LandOfFree
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