Icams immunoglobulin constant region soluble fusion proteins

Details Icams immunoglobulin constant region soluble fusion proteins Icams immunoglobulin constant region soluble fusion proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2123303

Soluble fusion molecules were prepared which contained a CD11a/CD18 specific binding region operatively linked to an immunoglobulin constant region. These molecules particularly include extracellular portions of adhesion molecules such as ICAM-1 and ICAM-2 attached to IgG constant regions. The fusion molecules described are utilized as costimulatory agents for the activation of T cells and in methods for increasing CD4+ T cell proliferative response and IL-2 induction.

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