C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/54 (2006.01) A61K 38/20 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2269638
The present invention relates to a peptide capable of binding to ICE and/or to enzymes of the ICE family which peptide consists essentially of the amino acid sequence of SEQ ID NO: I reported in the Sequence Listing, in which Xaa is selected between Asp and Ala, optionally containing one or more amino acids at its N-terminal and/or C- terminal end. It also relates to the use of the above peptide, for the preparation of pharmaceutical compositions active in pathologies requiring ICE inhibition and/or inhibition of enzymes of the ICE family.
La présente invention a trait à un peptide susceptible de se lier à une ICE et/ou à des enzymes de la famille des ICE, ce peptide consistant essentiellement en une séquence d'acides aminés de SEQ ID NO:1 mentionnée dans la liste des séquences, dans laquelle Xaa est sélectionné entre Asp et Ala, et contenant éventuellement un ou plusieurs acides aminés à son (ses) extrémité(s) N-terminale et/ou C-terminale. Cette invention a également trait à l'utilisation du peptide susmentionné, destiné à la préparation de compositions pharmaceutiques actives dans des pathologies requérant une inhibition d'ICE et/ou une inhibition d'enzymes de la famille des ICE.
Introna Martino
Mantovani Alberto
Muzio Marta
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Laboratoires Serono S.a.
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