Identification and characterization of a subset of...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2564654

The present invention relates to methods for in vitro diagnosing a cell proliferative disease in a mammal, for predicting the behaviour of a mammal having a cellproliferative disease in response to a medical treatment using at least one PDGF receptor antagonist, and for selecting a mammal having a cell proliferative disease and predicted to be responsive to a medical treatment using at least one PDGF receptor antagonist, by using given genetic markers.

Cette invention concerne des procédés permettant de diagnostiquer in vitro une maladie induisant la prolifération cellulaire chez un mammifère, de prévoir le comportement d'un mammifère atteint d'une maladie induisant la prolifération cellulaire en réaction à un traitement médical au moyen d'au moins un antagoniste du récepteur PDGF, et de sélectionner un mammifère atteint d'une maladie induisant la prolifération cellulaire et dont on prévoit qu'il sera sensible à un traitement médical au moyen d'au moins un antagoniste du récepteur PDGF, à l'aide des marqueurs génétiques donnés.

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