C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/50 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2336219
The present invention encompasses novel splice variant forms of the muopioid receptor-1 (KOR-3) and the polynucleotide sequences encoding the KOR-3 splice variants. The invention further encompasses methods of screening for compositions regulating the KOR-3 splice variant activities and the development of therapeutic modalities directed to regulating activity. Regulation of the KOR-3 splice variant activities may impact the physiologic processes of analgesia and weight management.
La présente invention se rapporte à de nouvelles formes de variants d'épissure du récepteur-1 opioïde-mu (KOR-3) et aux séquences polynucléotidiques codant les variants d'épissure de KOR-3. L'invention se rapporte également à des méthodes de détection de compositions régulant les activités des variants d'épissure de KOR-3 et le développement des modalités thérapeutiques associées à l'activité régulatrice. La régulation des activités des variants d'épissure de KOR-3 peut permettre d'influencer les processus physiologiques d'analgésie et de surveillance du poids.
Pan Ying-Xian
Pasternak Gavril
Memorial Sloan-Kettering Cancer Center
Smart & Biggar
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