C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01) G01N 33/94 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2452195
The present invention encompasses novel splice variant forms of the mu-opioid receptor-1 (MOR-1) and the polynucleotide sequences encoding the MOR-1 splice variants. The invention further encompasses methods of screening for compositions regulating the MOR-1 splice variant activities and the development of therapeutic modalities directed to regulating activity. Regulation of the MOR-1 splice variant activities may impact the physiologic process of analgesia.
L'invention concerne de nouvelles formes de variants d'épissures MOR-1 (mu-opioid receptor-1) ainsi que des séquences polynucléotidiques codant lesdits variants d'épissures de MOR-1. Par ailleurs, l'invention concerne des procédés de criblage de compositions régulant les différentes activités des variants d'épissures de MOR-1 et le développement de modalités thérapeutiques associées à l'activité régulatrice. La régulation des activités des variants d'épissures de MOR-1 peut influencer les processus physiologiques d'analgésie.
Pan Ying-Xian
Pasternak Gavril W.
Mbm Intellectual Property Law Llp
Memorial Sloan-Kettering Cancer Center
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