Identification and isolation of fetal cells and nucleic acid

Details Identification and isolation of fetal cells and nucleic acid Identification and isolation of fetal cells and nucleic acid

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2699958

The present invention provides methods, antibodies and kits useful for detecting the presence of a fetal cell and/or fetal nucleic acids in a biological sample obtained from a maternal host. It also provides methods and kits for isolating fetal nucleic acid from maternal cervical mucus samples, and for testing or screening the isolated fetal nucleic acid for genetic abnormalities in fetuses.

La présente invention concerne des procédés, des anticorps et des kits utiles pour détecter la présence d'une cellule ftale et/ou d'acides nucléiques ftaux dans un échantillon biologique obtenu auprès d'un hôte maternel. Elle concerne également des procédés et des kits pour isoler de l'acide nucléique ftal à partie d'échantillons de glaire cervicale maternelle, et pour tester ou cribler l'acide nucléique ftal isolé afin de détecter anomalies génétiques chez les ftus.

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