C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 9/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2250866
Novel polypeptides having WW domains of interest are described, along with DNA sequences that encode the same. A method of identifying these polypeptides by means of a sequence-independent (that is, independent of the primary sequence of the polypeptide sought), recognition unit-based functional screen is also disclosed. Various applications of the method and of the polypeptides identified are described, including their use in assay kits for drug discovery, modification, and refinement.
La présente invention décrit de nouveaux polypeptides ayant des domaines WW, ainsi que des séquences d'ADN codant pour lesdits polypeptides. Le procédé permet d'identifier les polypeptides au moyen d'un dispositif indépendant de la séquence (autrement dit, indépendant de la séquence primaire du polypeptide recherché), ainsi qu'un dispositif de crible fonctionnel basé sur une unité de reconnaissance. L'invention décrit également diverses applications du procédé et des polypeptides identifiés, y compris leur utilisation en kits d'analyse pour la découverte, la modification et le raffinage de médicaments.
Fowlkes Dana M.
Kay Brian K.
Pirozzi Gregorio
Cytogen Corporation
Smart & Biggar
University Of North Carolina At Chapel Hill
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