C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61P 7/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2422953
The invention provides for methods of modifying immunodominant epitopes on polypeptides, preferably polypeptides intended for therapeutic use. Knowledge of immunodominant epitopes prior to clinical use of polypeptides would be useful to design and engineer less immunogenic molecules. The invention provides for methods of identifying immunodominant epitopes and modifying an immunodominant epitope to reduce the immune response to the polypeptide while still retaining a substantial therapeutic activity of the polypeptide. The modified polypeptides are useful therapeutically.
L'invention concerne des procédés de modification d'épitopes immunodominants dans des polypeptides, de préférence des polypeptides destinés à un usage thérapeutique. Une connaissance des épitopes immunodominants avant une utilisation clinique des polypeptides peut s'avérer utile pour concevoir et créer des molécules moins immunogènes. L'invention concerne des procédés d'identification d'épitopes immunodominants et de modification d'un épitope immunodominant permettant de réduire la réponse immunitaire contre le polypeptide, tout en conservant une activité thérapeutique sensible du polypeptide. Les polypeptides modifiés sont thérapeutiquement utiles.
Koren Eugen
Lowe John Hok Nin
Genentech Inc.
Smart & Biggar
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