Identification and use of bacterial [2fe-2s] dihydroxy-acid...

Details Identification and use of bacterial [2fe-2s] dihydroxy-acid... Identification and use of bacterial [2fe-2s] dihydroxy-acid...

C - Chemistry, Metallurgy

12

N

C12N 9/88 (2006.01) C12P 7/16 (2006.01) C12P 7/40 (2006.01) C12P 13/06 (2006.01) C12P 13/08 (2006.01)

Patent

CA 2735690

A group of bacterial dihydroxy-acid dehydratases having a [2Fe-2S] cluster was discovered. Bacterial [2Fe-2S] DHADs were expressed as heterologous proteins in bacteria and yeast cells, providing DHAD activity for conversion of 2,3-dihy- droxyisovalerate to .alpha.-ketoisovalerate or 2,3-dihydroxymethylvalerate to .alpha.-ketomethylvalerate. Isobutanol and other compounds may be synthesized in pathways that include bacterial [2Fe-2S] DHAD activity.

Linvention concerne un groupe de dihydroxyacide déshydratases bactériennes possédant un agrégat [2Fe-2S]. Des DHAD [2Fe-2S] bactériennes ont été exprimées en tant que protéines hétérologues dans des bactéries et des cellules de levure, fournissant une activité de DHAD pour la conversion de 2,3-dihydroxyisovalérate en a-cétoisovalérate ou de 2,3-dihydroxyméthylvalérate en a-cétométhylvalérate. Il est possible de synthétiser de lisobutanol et dautres composés dans des voies qui incluent une activité de DHAD [2Fe-2S] bactérienne.

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