C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 38/04 (2006.01) A61K 38/08 (2006.01) C07K 14/72 (2006.01) C12N 15/12 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2655849
The invention relates genes that are deregulated in Parkinson's disease tissues and the corresponding proteins are identified. These genes and the corresponding proteins are suitable targets for the treatment of Parkinson's disease. Also, the invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention more specifically relates to new uses of compounds that activate the B2 bradykinin receptor, for treating neurodegeneration involving oxidative stress and, more particularly, Parkinson's disease. The invention also relates to corresponding methods of treatment, and can be used in human subjects for preventive or curative treatment, either alone or in combination with other active agents or treatments.
La présente invention concerne des gènes dérégulés dans les tissus atteints de la maladie de Parkinson dont les protéines correspondantes sont identifiées. Ces gènes et les protéines correspondantes sont des cibles possibles pour le traitement de la maladie de Parkinson. L'invention concerne également des composés et leurs emplois, notamment dans l'industrie pharmaceutique. Plus particulièrement, l'invention concerne de nouveaux emplois de composés qui activent le récepteur B2 de la bradykinine pour le traitement de neurodégénérescences avec stress oxydant, notamment la maladie de Parkinson. Enfin, l'invention concerne des procédés thérapeutiques correspondants et peut être utilisée sur des sujets humains pour un traitement préventif ou curatif, seule ou associée à d'autres actifs ou traitements.
Kong Dehe
Kotraiah Vinayaka
Pando Matthew Paul
Exonhit Therapeutics Sa
Robic
LandOfFree
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