Identification and use of protease inhibitors

Details Identification and use of protease inhibitors Identification and use of protease inhibitors

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/17 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 38/05 (2006.01) A61K 38/55 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2129689

ABSTRACT .beta.-amyloid peptide (.beta.AP) production in cell culture and in vivo is inhibited by administering aspartyl protease inhibitors, particularly inhibitors of proteases of cathepsin D. Useful aspartyl protease inhibitors can be selected in a two-step assay, where test compounds are first screened for aspartyl protease inhibition activity in vitro in non- cellular assays. Those test compounds which are found to display protease inhibition activity are then tested in cellular assays for .beta.AP production inhibition. Those test compounds which are capable of inhibiting intracellular .beta.- amyloid production may be incorporated in pharmaceutical compositions.

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