Identification of a cdna associated with ischemia in human...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/63 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 16/00 (2006.01) C12N 1/20 (2006.01) C12N 9/00 (2006.01) C12N 9/12 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2323574

A new gene that is up-regulated in ischemic heart tissue is described. Also described are nucleic acid molecules that contain the new gene. These nucleic acid molecules may be operably linked to one or more expression control elements to produce, for example, a vector for transforming host cells. By culturing such host cells under proper conditions, protein from the new gene may be expressed and purified.

La présente invention concerne un nouveau gène régulé positivement dans un tissu cardiaque ischémique. L'invention concerne également des molécules d'acide nucléique renfermant le nouveau gène. Ces molécules d'acide nucléique peuvent être liées de façon fonctionnelle à un ou plusieurs éléments de régulation d'expression pour produire, par exemple, un vecteur de transformation de cellules hôtes. En mettant en culture ces cellules hôtes dans des conditions appropriées, la protéine du nouveau gène peut être exprimée et purifiée.

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