Identification of a human cytomegalovirus gene involved in...

Details Identification of a human cytomegalovirus gene involved in... Identification of a human cytomegalovirus gene involved in...

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/34 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2328638

Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down-regulation of cell surface expression of MHC class I. A recombinant mutant HCMV which fails to down-regulate class I heavy chain expression is described. A method of controlling down-regulation of MHC class I expression in a cytomegalovirus infected cell, a pharmaceutical composition, a vaccine composition, a method of preventing or reducing susceptibility to acute cytomegalovirus in an individual, and a virus based gene therapy vector are also described.

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