A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2659364
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of .beta.-myosin heavy chain (.beta.-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.
La présente invention concerne l'identification d'un microARN, miR 208, qui induit l'expression de la chaîne lourde .beta.-myosine (.beta.-MHC) et réprime les gènes rapides de protéines contractiles du muscle squelettique. L'inhibition de cette fonction est proposée comme un traitement de la fibrose cardiaque, de l'hypertrophie et/ou de l'insuffisance cardiaque, et l'augmentation de cette fonction peut être utilisée pour réprimer des gènes lents des fibres et activer les gènes rapides des fibres dans le traitement de troubles musculosquelettiques.
Olson Eric
Rooij Eva Van
Board Of Regents Of The University Of Texas System
Deeth Williams Wall Llp
LandOfFree
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