Identification of a novel bitter taste receptor, t2r76

Details Identification of a novel bitter taste receptor, t2r76 Identification of a novel bitter taste receptor, t2r76

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 45/00 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2488863

Isolated nucleic acids encoding T2R76 polypeptides , recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76-modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably a different human T2R polypeptide.

La présente invention a trait à des acides nucléiques isolés codant pour des polypeptides T2R76, des polypeptides T2R76 exprimés en recombinaison, des systèmes d'expression hétérologues pour l'expression recombinante de polypeptides T2R76, des procédés de dosage mettant en oeuvre tels polypeptides T2R76, et des procédés pour la modification de la perception gustative par l'administration d'un modulateur de TR276. Ces polypeptides T2R76 peuvent être exprimés seuls ou en expression conjointe avec un autre polypeptide T2R, de préférence un polypeptide T2R humain différent.

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