C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 31/00 (2006.01) A61K 31/197 (2006.01) A61K 35/76 (2006.01) A61K 38/46 (2006.01) A61K 38/48 (2006.01) A61K 45/06 (2006.01) C12N 9/14 (2006.01) C12N 9/50 (2006.01) C12N 9/80 (2006.01) C12N 15/33 (2006.01) C12Q 1/04 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2486280
A method and composition for treating a Bacillus anthracis infection is disclosed which comprises the steps of: administering to the site of an infection or colonization an effective amount of at least one lytic enzyme genetically coded for by a bacteriophage specific for Bacillus anthracis, wherein said at least one said lytic enzyme is specific for and has the ability to digest a cell wall of said Bacillus anthracis. The lytic enzyme may be chimeric or shuffled, and a holin protein may also be used. The sequence for the lytic enzyme gamma bacteriophage is disclosed.
L'invention concerne un procédé et une composition pour traiter l'infection à Bacillus anthracis, qui consiste en ce qui suit: administrer sur le site d'une infection ou de colonisation une quantité efficace d'au moins une enzyme lytique génétiquement codée par un bactériophage spécifique à Bacillus anthracis, ladite au moins une enzyme lytique étant spécifique à la paroi cellulaire de Bacillus anthracis et étant capable de la digérer. L'enzyme lytique peut être chimère ou remaniée, et on peut aussi utiliser une protéine holine. L'invention concerne aussi la séquence d'un bactériophage gamma de l'enzyme lytique.
Fischetti Vincent A.
Loomis Lawrence
Nelson Daniel
Schuch Raymond
Trudil David
Fischetti Vincent A.
Loomis Lawrence
Nelson Daniel
New Horizons Diagnostics Corporation
Schuch Raymond
LandOfFree
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