A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 31/137 (2006.01) A61K 31/198 (2006.01) A61K 31/216 (2006.01) A61K 31/4706 (2006.01) A61K 38/00 (2006.01) A61K 38/07 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 31/00 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2265896
The present invention is directed to methods for identifying agents that inhibit the toxic effects of neurotoxins on neurons from plaque component activated mononuclear phagocytes. In addition, the present invention is directed to methods of identifying agents that inhibit mononuclear phagocyte- plaque component complex formation, plaque component activation of mononuclear phagocytes, and plaque component induced neurotoxicity of mononuclear phagocytes. The present invention is also directed to agents and pharmaceutical compositions obtained by the identification methods described herein. Additionally, the present invention describes methods for using tyramine compounds to inhibit the toxic effects of neurotoxins and methods to treat and diagnose neurodegenerative diseases and disorders.
La présente invention concerne des procédés d'identification d'agents inhibant les effets toxiques sur des neurones de neurotoxines provenant de phagocytes mononucléés activés par des composants de plaques séniles. En outre, la présente invention concerne des procédés d'identification d'agents inhibant la formation d'un complexe phagocytes mononucléés-composants de plaques séniles, l'activation par des composants de plaques séniles de phagocytes mononucléés, et la neurotoxicité de phagocytes mononucléés induite par des composants de plaques séniles. La présente invention concerne également des agents et des compositions pharmaceutiques produits par les procédés d'identification décrits ici, ainsi que des procédés d'utilisation de composés de tyramine pour l'inhibition des effets toxiques de neurotoxines et des procédés permettant le diagnostic et le traitement d'affections et de troubles neurodégénératifs.
Baylor College Of Medicine
Mcfadden Fincham
LandOfFree
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