C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2470088
There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the ACK1 gene, which are amplified breast and/or ovarian and/or prostate cancer genes. The ACK1 gene, its expressed protein products and antibodies are used diagnostically or as targets for cancer therapy or vaccine; they also are used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.
L'invention concerne des méthodes et des compositions destinées au diagnostic, à la prévention et au traitement des tumeurs et des cancers chez les mammifères, par exemple, notamment les humains, au moyen des gènes ACK1, qui sont des gènes amplifiés du cancer du sein et/ou de l'ovaire et/ou de la prostate. Les gènes ACK1, leurs produits protéiniques exprimés et leurs anticorps sont utilisés à des fins diagnostiques ou en tant que cibles pour une thérapie anticancéreuse ou un vaccin anticancéreux ainsi que pour identifier des composés et des réactifs utiles pour le diagnostic, la prévention et le traitement du cancer.
Degenhardt Yan Y.
Powers Scott
Smart & Biggar
Tularik Inc.
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