C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2271954
The present invention provides the amino acid and nucleotide sequence of a protein that binds to .beta.3 integrins, .alpha.IIb and Src kinase and is involved in integrin mediated signaling. Based on this disclosure, the present invention provides methods for identifying agents that block integrin mediated signaling, methods of using agents that block integrin mediated signaling to modulate biological and pathological processes, and agents that block integrin mediated signaling.
La présente invention concerne l'acide aminé et la séquence nucléotidique d'une protéine se liant à des intégrines .beta.3, .alpha.IIb et Src kinase, et intervenant dans la transduction de signaux par intégrine. Sur la base de cette découverte, la présente invention concerne des procédés d'identification d'agents bloquant la transduction de signaux par intégrine, des procédés d'utilisation d'agents bloquant la transduction de signaux par intégrine pour moduler des procédés biologiques et pathologiques, et des agents bloquant la transduction de signaux par intégrine.
Li Shengfeng
Phillips David R.
Cor Therapeutics Inc.
Deeth Williams Wall Llp
Millennium Pharmaceuticals Inc.
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