Identification of broadly reactive dr restricted epitopes

Details Identification of broadly reactive dr restricted epitopes Identification of broadly reactive dr restricted epitopes

G - Physics

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G01N 33/574 (2006.01) A61K 39/00 (2006.01) A61K 39/015 (2006.01) A61K 39/21 (2006.01) A61K 39/29 (2006.01) A61K 39/395 (2006.01) A61K 39/42 (2006.01) C07K 16/00 (2006.01) C12N 7/00 (2006.01) C12N 15/869 (2006.01) G01N 33/53 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2332786

The present invention is based, at least in part, on the discovery and validation of specific immunogenic peptide epitopes for various HLA class II DR molecules, representative of the worldwide population. Such peptides comprise an epitope, or analog thereof, which binds to an HLA class II molecule at an IC50 of less than or equal to 1,000 nM.

La présente invention s'appuie, au moins en partie, sur la découverte et l'utilisation d'épitopes peptidiques immunogènes spécifiques pour diverses molécules DR HLA de la classe II, représentatives de la population mondiale. Ces peptides renferment un épitope, ou un analogue de celui-ci, qui se fixe à une molécule HLA de la classe II selon une capacité IC¿50? inférieure ou égale à 1000 nM.

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