Identification of broadly reactive dr restricted epitopes

Details Identification of broadly reactive dr restricted epitopes Identification of broadly reactive dr restricted epitopes

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 39/02 (2006.01) A61K 39/10 (2006.01) A61K 39/12 (2006.01) C07H 21/04 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 14/005 (2006.01) C07K 14/02 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C07K 14/195 (2006.01) C07K 14/20 (2006.01) C07K 14/445 (2006.01) C07K 14/725 (2006.01) C07K 14/74 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2278296

The present invention is based on peptide binding specificities of HLA DR4w4, DR1 and DR7. Peptides binding to these DR molecules have a motif characterized by a large aromatic or hydrophobic residue in position 1 (Y, F, W, L, I, V, M) and a small, non charged residue in position 6 (S, T, C, A, P, V, I, L, M). In addition, allele-specific secondary effects and secondary anchors are defined, and these results were utilized to derive allele specific algorithms. By the combined use of such alogirthms peptides capable of degenerate DR1, 4, 7 binding were identified.

La présente invention concerne des spécificités de liaison peptidique de HLA, DR4w4, DR1 et DR7. Les peptides liés à ces molécules DR présentent un motif structural caractérisé par un gros reste aromatique ou hydrophobe en position 1 (Y, F, W, L, I, V, M) et un petit reste non chargé en position 6 (S, T, C, A, P, V, I, L, M). En outre, l'invention définit les effets secondaires et les ancres secondaires spécifiques aux allèles, dont les résultats ont été utilisés pour dériver des algorithmes spécifiques aux allèles. L'utilisation combinée de tels algorithmes a permis d'identifier des peptides capables de liaison DR1, 4, 7 dégénérée.

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