Identification of cancer stem cells using genetic markers

Details Identification of cancer stem cells using genetic markers Identification of cancer stem cells using genetic markers

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2662843

The invention relates to the identification of markers for cancer stem cells. These markers can be used in a number of different ways, including diagnosis and therapy. In particular, the invention relates to a method of detecting, identifying and/or quantifying cancer stem cells, the method comprising the step of assessing the level of expression; the activity; or the sequence of the SLUG, OVOLl and/or OVOL2 gene, promoter and/or expression product in a cell.

La présente invention concerne l'identification de marqueurs pour des cellules souches cancéreuses. Lesdits marqueurs peuvent être utilisés de nombreuses manières différentes, notamment dans le cadre de diagnostics et de thérapies. En particulier, la présente invention concerne un procédé de détection, d'identification et/ou de quantification de cellules souches cancéreuses. Ledit procédé comprend l'étape consistant à évaluer le niveau d'expression, l'activité, ou la séquence des gènes SLUG, OVOLl et/ou OVOL2, du promoteur et/ou du produit d'expression dans une cellule.

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