C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) A61K 35/14 (2006.01) A61K 39/395 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2713462
This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8+ T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18R.alpha. and the capacity to rapidly efflux the fluorescent dye Rh123.
Cette invention porte, entre autres, sur des procédés d'identification et d'isolement de sous-ensembles (CMhi et EMhi) de lymphocytes CD8+ mémoires, spécifiques d'un antigène, à longue durée de vie, putatifs, viables avec une expression de surface élevée de CD161 et/ou IL-18Ra (ALPHA) et la capacité d'écouler rapidement le colorant fluorescent Rh123.
Riddell Stanley R.
Turtle Cameron J.
Fred Hutchinson Cancer Research Center
Smart & Biggar
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