G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2609558
The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.
La présente invention concerne des méthodes d'identification de composés capables de moduler une réponse cellulaire. Ces méthodes consistent à fixer des cellules vivantes sur des supports solides comprenant une banque de composés d'essai. Ces composés d'essai sont reliés aux supports solides par des lieurs clivables et peuvent donc être libérés desdits supports. Comme on sélectionne des supports solides qui renferment des cellules dont la réponse d'intérêt a été modulée, il est possible d'identifier le composé d'essai. La réponse cellulaire peut se traduire, notamment, par des changements survenus dans une formation complexe entre protéines.
Hagel Grith
Hentzer Morten
Meldal Morten
Norrild Jens Chr.
Thastrup Ole
2curex
Carlsberg A/s
Macpherson Leslie & Tyerman Llp
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