Identification of compounds modifying a cellular response

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/06 (2006.01) C07K 7/00 (2006.01) C07K 17/02 (2006.01) C12Q 1/02 (2006.01) C40B 30/06 (2006.01) C40B 40/04 (2006.01) C40B 40/10 (2006.01) C40B 50/00 (2006.01) C40B 50/14 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2568168

The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. Test compounds modulating a cellular response, for example via a cell surface molecule may be identified by selecting solid supports comprising cells, wherein the cellular response of interest has been modulated. The cellular response may for example be changes in signal transduction pathways modulated by a cell surface molecule.

L'invention concerne des procédés pour identifier des composés pouvant moduler une réponse cellulaire. Ces procédés consistent à fixer des cellules vivantes à des supports solides comprenant une banque de composés à tester. Les composés testés modulant une réponse cellulaire, par exemple par l'intermédiaire d'une molécule de surface cellulaire, peuvent être identifiés par sélection des supports solides comprenant des cellules dans lesquelles la réponse cellulaire présentant un intérêt a été modulée. Cette réponse cellulaire peut par exemple se manifester sous la forme de modifications des voies de transduction du signal modulées par une molécule de surface cellulaire.

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