Identification of factors which mediate the interaction of...

Details Identification of factors which mediate the interaction of... Identification of factors which mediate the interaction of...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12N 5/10 (2006.01) C12N 9/16 (2006.01) C12N 15/63 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2319037

Monomeric GTPase guanine nucleotide exchange factor (GEF) have been identified which also contain an RGS region analogous to those of GTPase activating proteins (GAP). One of these GEF proteins, a Rho GEF has been demonstrated to contain an RGS sequence that has GAP activity toward a .alpha. subunit of a heterotrimeric G prote in.

Des facteurs d'échange de nucléotides de guanine (GEF) de GTPase monomères ont été identifiés, ces facteurs renfermant une région RGS analogue à celle des protéines activant la GTPase (GAP). L'une de ces protéines GEF, ci-après dénommée Rho GEF, renferme une séquence RGS présentant une activité GAP à l'encontre d'une sous-unité .alpha. d'une protéine G hétérotrimère.

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