Identification of gene expression alterations underlying the...

Details Identification of gene expression alterations underlying the... Identification of gene expression alterations underlying the...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A23L 1/29 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C07H 19/00 (2006.01) C07H 21/02 (2006.01) C12P 19/34 (2006.01) C12P 21/06 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2441086

A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment, the steps of: (a) obtaining a sample of nucleic acid isolated form the organism's organ, tissue or cell, wherein the nucleic acid is RNA or a cDNA copy of RNA and (b) determining the gene expression pattern of at least one the genes selected from the group consisting of M21050, Z49204, U49430, K02782, X58861, X66295, M22531, M22531, X67809, U19118, M64086, M63695, U39066, X92590, X56518, AA182189, X16493, U20344, X16834, X82648, D00754, D16313, L38971 and X15789.

L'invention concerne un procédé de mesure de l'âge biologique d'un organisme multicellulaire. Dans un mode de réalisation, ce procédé consiste : (a) à prélever un échantillon d'acide nucléique isolé d'un organe de l'organisme, d'un tissu ou d'une cellule, l'acide nucléique étant ARN ou une copie ADNc de ARN et (b) à déterminer le schéma d'expression génétique d'au moins un des gènes choisis dans le groupe M21050, Z49204, U49430, K02782, X58861, X66295, M22531, M22531, X67809, U19118, M64086, M63695, U39066, X92590, X56518, AA182189, X16493, U20344, X16834, X82648, D00754, D16313, L38971 et X15789.

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