Identification of high affinity molecules by limited...

Details Identification of high affinity molecules by limited... Identification of high affinity molecules by limited...

G - Physics

01

N

G01N 33/53 (2006.01) G01N 33/557 (2006.01)

Patent

CA 2478547

Methods are disclosed for determining the relative binding affinities of molecules for their binding partner. One type of molecule is an antibody, which has an antigen binding partner. Antibodies are tested for binding against limited dilutions of antigen. Antibodies that bind to the most dilute antigen concentrations are determined to have a higher relative binding affinity for the antigen than antibodies that only bind to more concentrated antigen preparations.

L'invention concerne des procédés de détermination des affinités de liaison relatives de molécules pour leur partenaire de liaison. Un type considéré de molécule est un anticorps présentant un antigène comme partenaire de liaison. Des anticorps sont soumis à des tests portant sur la liaison à l'encontre de dilutions limitées d'antigène. Des anticorps se liant à des concentrations les plus diluées en antigènes sont classés comme présentant une affinité de liaison relative plus élevée que des anticorps qui se lient uniquement à des préparations d'antigènes plus concentrées.

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