G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01)
Patent
CA 2671912
The present invention relates to a method of identifying an immunologically effective epitope, the method comprising: a) preparing an oligomer of a protein present on the surface of a red blood cell which includes a polymorphism therein and b) ascertaining whether the oligomer stimulates T-cells and a composition comprising an immunologically effective epitope for the tolerisation of a subject that has been exposed to an antithetical allele.
La présente invention concerne, d~une part, un procédé d~identification d~un épitope immunologiquement actif comprenant : a) la préparation d~un oligomère d~une protéine présente à la surface d~un érythrocyte contenant un polymorphisme et b) l~identification ou non d~une stimulation des lymphocytes T par l~oligomère et, d~autre part, une composition contenant un épitope immunologiquement actif pour la tolérisation d~un sujet ayant été exposé à un allèle antithétique.
Barker Robert Norman
Urbaniak Stanislaw Joseph
Aberdeen University
Riches Mckenzie & Herbert Llp
The Common Services Agency For The Scottish Health Service
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