C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2167048
A method of detecting a substance capable of acting as a ligand, the method comprising: (a) incubating, under conditions permitting cell amplification, cells transfected with DNA coding for a receptor capable of influencing cell amplification in response to a ligand, the cells comprising a marker of cell amplification, with a test substance which is a potential agonistor antagonist of the receptor, and (b) after a period of time sufficient to permit cell amplification determining the presence or absence of amplification of cells containing the marker relative to cells not containing the marker.
Procédé de détection d'une substance susceptible d'agir comme un ligand, le procédé consistant: (a) à incuber, dans des conditions permettant l'amplification cellulaire, des cellules transfectées avec un ADN codant pour un récepteur apte à influencer l'amplification cellulaire en réponse à un ligand, ces cellules comprenant un marqueur d'amplification cellulaire, au moyen d'une substance d'essai qui est un agoniste ou un antagoniste potentiel du récepteur, et (b) à déterminer, après un laps de temps suffisant pour permettre l'amplification cellulaire, la présence ou l'absence d'amplification des cellules contenant le marqueur, par rapport aux cellules qui ne contiennent pas ce dernier.
Acadia Pharmaceuticals Inc.
Brann Mark Robert
Mccarthy Tetrault Llp
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