Identification of modulators of the marr family proteins

Details Identification of modulators of the marr family proteins Identification of modulators of the marr family proteins

C - Chemistry, Metallurgy

12

Q

C12Q 1/18 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2370426

Assays for identifying compounds which modulate the ability of MarR family polypeptides to bind to DNA and to negatively or positively regulate the transcription of genetic loci are disclosed herein. The instant assays detect the ability of compounds to bind to and/or regulate the activity of MarR family polypeptides. The invention provides, inter alia, MarR family polypeptides and methods of their use.

La présente invention concerne des analyses permettant d'identifier des composés qui modulent la capacité des polypeptides de la famille MarR à se lier à l'ADN et à réguler positivement ou négativement la transcription des loci génétiques. Ces analyses instantanées détectent la capacité des composés à se lier aux polypeptides de la famille MarR et/ou à réguler leur activité. L'invention se rapporte, entre autres, à des polypeptides de la famille MarR et à des procédés d'utilisation de ces derniers.

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