C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/48 (2006.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 39/21 (2006.01) A61K 39/295 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 31/18 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C12N 15/49 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12Q 1/70 (2006.01) G01N 33/50 (2006.01) G01N 33/554 (2006.01)
Patent
CA 2462162
The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and nucleic acid sequence coding for these peptides derived from HIV-1 proteins such as GAG, POL, ENV, VIF, TAT, VPU, REV and their applications.Preferably the immunogenic peptides are selected from the group consisting of SEQ ID NOs:1 to 18 and functional derivatives thereof.The invention also relates to antibodies directed against said peptides.
L'invention concerne l'identification et la sélection d'épitopes CTL capables d'induire une protection contre une infection par le VIH. L'invention concerne plus particulièrement des peptides et des séquences d'acide nucléique codant ces peptides, obtenus à partir de protéines du VIH-1, telles que GAG, POL, ENV, VIF, TAT, VPU, REV, et leurs applications. Les peptides immunogènes sont avantageusement sélectionnés dans le groupe comprenant les séquences SEQ ID NO : 1 à 18 et leurs dérivés fonctionnels. L'invention concerne également des anticorps dirigés contre ces peptides.
Cardinaud Sylvain
Habel Andre
Langlade-Demoyen Pierre
Lemonnier Francois
Institut National de La Sante Et de La Recherche Medicale
Institut Pasteur
Robic
LandOfFree
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