C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61P 25/04 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2749824
The invention relates to a peptide having the following sequence YCQKFLWTCDSERPCCEGLVCRLWCKIN (SEQ ID NO 1) or a derivative thereof, and to nucleic acids coding for the peptide having the sequence (SEQ ID NO 1). The invention also relates to the use of this peptide as an antagonist and/or reverse agonist of T-type calcium channels. The invention further relates to a use of the peptide for preparing a drug, in particular an analgesic one.
L'invention se rapporte un peptide de séquence YCQKFLWTCDSERPCCEGLVCRLWCKIN (SEQ ID NO 1) OU un dérivé de celui-ci et aux acides nucléiques codant pour le peptide de séquence SEQ ID NO 1. La présente invention se rapporte également à l'utilisation dudit peptide comme antagoniste et/ou agoniste inverse de canaux calciques de type T. La présente invention se rapporte également à l'utilisation du peptide pour la fabrication d'un médicament, notamment d'un analgésique.
Bourinet Emmanuel
Escoubas Pierre
Lazdunski Michel
Marger Fabrice
Nargeot Joel
Centre National de La Recherche Scientifique (c.n.r.s.)
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universite de Nice - Sophia Antipolis
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