C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C07K 16/10 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01) G01N 33/554 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2484930
The present invention provides a method of identifying novel broadly cross~reactive neutralizing monoclonal antibodies using sequential antigen panning of phage display libraries, antibodies obtained in accordance with such a method, as well as fusion proteins and conjugates comprising same, and related isolated or purified nucleic acid molecules, vectors, host cells, compositions, and methods of use to inhibit an infection, reduce the severity of an infection, treat an infection, and inhibit cancer.
L'invention concerne un procédé d'identification d'anticorps monoclonaux humains largement neutralisants a réaction croisée au moyen d'un procédé d'adhérence séquentielle sur plaque de banques de présentation du phage, des anticorps obtenus selon un tel procédé ainsi que des protéines de fusion et des conjugués comprenant ces protéines. Elle concerne aussi des acides nucléiques associés isolés ou purifiés, des vecteurs, des cellules hôtes, des compositions et des procédés d'utilisation destinées à inhiber une infection, diminuer la sévérité d'une infection, traiter une infection et inhiber le cancer.
Dimitrov Dimiter S.
Zhang Mei-Yun
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Ridout & Maybee Llp
LandOfFree
Identification of novel broadly cross-reactive neutralizing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Identification of novel broadly cross-reactive neutralizing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of novel broadly cross-reactive neutralizing... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1394955