Identification of peripheral benzodiazepine receptor binding...

Details Identification of peripheral benzodiazepine receptor binding... Identification of peripheral benzodiazepine receptor binding...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2406901

The invention provides methods for screening for agents that modulate mitochondrial membrane potential. Such agents generally bind to a peripheral benzodiazepine receptor and may be detected by direct binding assays or by indirect or functional assays. Agents identified using the screens provided herein have application in the prevention and treatment of a variety of diseases associated with abnormal mitochondrial function.

L'invention concerne des procédés pour cribler les substances à la recherche d'agents qui modulent le potentiel de membrane mitochondriale. Ces agents se lient généralement à un récepteur de benzodiazépine périphérique et peuvent être détectés par dosage de liaison directs ou par dosages indirects ou fonctionnels. Les agents identifiés au moyen de dispositifs de criblage de l'invention peuvent s'utiliser dans la prévention et le traitement de diverses maladies associées à la fonction mitochondriale anormale.

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