A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/46 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2593541
A peptide of phospholipase A2 had been detected in human plasma and synthesised. The peptide was injected into mice and gene expression profiling on many organs performed. Phospholipase A2 showed significant effects on regulation of gene expression in the liver. The genes affected are members of the integrin signalling pathway, wnt pathway and PTEN pathway. The changes in gene expression indicate a positive effect of phospholipase A2 on cell proliferation and invasiveness. The gene annotation points at colorectal cancer.
L'invention concerne la détection d'un peptide de la phospholipase A2 dans du plasma humain et la synthèse de celui-ci. Le peptide a été injecté dans une souris et le profilage de l'expression génique exécuté sur plusieurs organes. La phospholipase A2 présente des effets importants sur la régulation de l'expression génique dans le foie. Les gènes touchés sont des éléments de la voie de signalisation de l'intégrine, de la voie wnt et de la voie PTEN. Les changements dans l'expression génique indiquent un effet positif sur la phospholipase A2 sur la prolifération cellulaire et le pouvoir envahissant. L'annotation génique indique un cancer colorectal.
Papoian Ruben
Scherer Andreas
Fetherstonhaugh & Co.
Novartis Ag
LandOfFree
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